Sega Master System / Mark III / Game Gear
Here's another arcade conversion that made it onto computers before the consoles, and did well for itself. With only two joystick ports and no keyboard there obviously isn't the three player option, but it should satisfy most people as a twosome.
The idea is simple enough and merely requires a love of destruction on a grand scale to enjoy. As a mutated monster - amazing what food additives can do - you' re going round in a fit of rage beating seven colours of brick out of America's cities. All you have to is clamber up the sides of buildings and smash them up until they collapse to the ground in a cloud of dust.
Each city is defended by helicopters, tanks and men with guns, and there are surprises both tasty and unpleasant inside the rooms of the buildings. Not much of this has a big effect on health, but attrition on the monsters will eventually turn them back into humans and end the game. Best as a two player game but gets repetitive in the extreme.